Soluble angiogenic factors: Implications for chronic myeloproliferative disorders
نویسندگان
چکیده
منابع مشابه
Chronic Myeloproliferative Disorders
JAK2, an acquired mutation of JAK2, is present in a majority of patients with polycythemia vera and to a lesser extent among patients with the other myeloproliferative disorders. We analyzed the effect of JAK2 on the expression of polycythemia rubra vera 1(PRV-1), using an in vitro model. Compared to wild-type JAK2, the presence of JAK2 increased both PRV-1 protein and mRNA levels in murine mye...
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The Philadelphia chromosome-negative chronic myeloproliferative disorders (CMPD), polycythemia vera (PV), essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (IMF), have overlapping clinical features but exhibit different natural histories and different therapeutic requirements. Phenotypic mimicry amongst these disorders and between them and nonclonal hematopoietic disorders, la...
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We report on three autopsy cases with clinical and morphological evidence of pulmonary hypertension and concurrent myeloproliferative disorders. Massive accumulations of pleomorphic, atypical megakaryocytes and thrombotic material are found within the pulmonary capillary beds. Morphometrical studies allowed us to identify on average 1,293.4 (1,145.8-1,401) megakaryocytes per one square centimet...
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We evaluated factor IX activation peptide and soluble adhesion molecules of the selectin class (endothelial, leukocyte and platelet) in a group of patients affected by chronic myeloproliferative disorders (essential thrombocythemia and polycythemia vera) with high platelet counts in a stable condition. Using these markers, we could not demonstrate evidence of hypercoagulability or endothelial d...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2002
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.10020